Evaluation of the Wound Healing Activity of the Crude Extract of Leaves of Acanthus polystachyus Delile (Acanthaceae)
Table 3
Effect of topical application of 80% methanolic crude extract ointment of the leaves of A. polystachyus on wound contraction of infected wound model in mice.
Days
SO
NF
5 CEO
10 CEO
Wound area (mm2), after wounding days
0
298.20 ± 6.84
301.21 ± 6.15
298.69 ± 6.84
301.21± 6.15
2
278.81± 9.13
259.45 ± 8.73
268.87 ± 6.50
259.19 ± 4.84
4
254.87 ± 10.32
205.81 ± 10.09
213.9 ± 5.79
201.22 ± 6.49
6
214.44 ± 11.01
144.31± 11.38
150.86 ± 8.81
126.91± 9.81
8
186.57 ± 17.40
85.04 ± 8.72
96.03 ± 9.23
67.38 ± 8.47
10
156.22 ± 17.46
43.70 ± 6.69
56.00 ± 8.15
27.74 ± 6.98
12
120.24 ± 19.51
19.63 ± 5.73
27.09 ± 8.02
7.07 ± 3.18
14
107.02 ± 18.87
5.63 ± 3.14
11.12 ± 5.52
1.70 ± 1.19
16
85.31 ± 18.59
0.66 ± 0.51
2.49 ± 3.56
0.00 ± 0.00
18
68.04 ± 16.99
0.00 ± 0.00
0.00 ± 0.00
0.00 ± 0.00
Note: SO, simple ointment base; CEO, crude extract ointment; NF, nitrofurazone; = 6 animals in each group. Values are expressed as mean ± SEM (n = 6), one-way ANOVA. Against negative control, P < 0.05, P < 0.01, andP < 0.001.
