Bogijetong Decoction and Its Selected Formulation Are Involved in Alleviating Neuropathic Pain in a Rat Model of Chronic Constrictive Injury
Regulation of Erk1/2 activation in the sciatic nerve and DRG after CCI and BGJTD/BeD treatments. (a, c) Western blot analysis of phospho-Erk1/2 in the sciatic nerve (a) and in the DRG (c). (b) Immunofluorescence images of phospho-Erk1/2 in the sciatic nerve. These are the representative images from an animal treated with CCI+BeD. Western blotting for actin was used as an internal loading control. Bar graphs in (a) and (c) represent quantification of relative band intensity to actin. Error bar (mean ± SEM, n=4). p<0.01, p<0.001 vs. control group. +++p<0.001 vs. CCI+SAL group. Scale bar = 100 μm.
Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.