Qi-Dong-Huo-Xue-Yin Inhibits Inflammation in Acute Lung Injury in Mice via Toll-Like Receptor 4/Caveolin-1 Signaling

Figure 1

Effects of QDHXY on pathological changes in the lung tissues of mice with LPS-induced ALI. Mice were pretreated with QDHXY (0.4 or 0.8 g) or dexamethasone (0.1 mg) daily for 6 days. They were then administered 50 μL of 1 mg/mL LPS by endotracheal instillation on day 5. The five groups were, respectively, labeled as normal control, ALI, ALI + LDQ (LPS and low-dose QDHXY), ALI + HDQ (LPS and high-dose QDHXY), and ALI + DEX (LPS and dexamethasone). Changes in lung tissue were observed under a microscope. The red and black arrows show thickening of the alveolar septum and pulmonary congestion, respectively. The yellow and blue arrows show the lung parenchyma with alveolar atrophy or expansion and pulmonary bullae formation due to alveolar fusion and expansion, respectively. The green arrows show inflammatory cell infiltration. Magnification: ×200.