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Evidence-Based Complementary and Alternative Medicine
Volume 2018, Article ID 2373609, 11 pages
https://doi.org/10.1155/2018/2373609
Research Article

Qi-Dong-Huo-Xue-Yin Inhibits Inflammation in Acute Lung Injury in Mice via Toll-Like Receptor 4/Caveolin-1 Signaling

1Department of Emergency, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China
2Department of Respiratory Medicine, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China
3Department of Laboratory Medicine, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China
4Animal Experimental Center, Zhejiang Chinese Medical University, Hangzhou, China
5Accident and Emergency Department, Royal Free London NHS Foundation Trust, London, UK

Correspondence should be addressed to Li-Ying Xu; nc.ude.umcz@6121ylux and Wan-Ru Cai; moc.nuyila@urnawiac

Received 6 November 2017; Accepted 14 January 2018; Published 11 February 2018

Academic Editor: Caigan Du

Copyright © 2018 Li-Ying Xu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. American Thoracic Society, “Round table conference: Acute lung injury,” American Journal of Respiratory and Critical Care Medicine, vol. 158, no. 2, pp. 675–679, 1998. View at Publisher · View at Google Scholar · View at Scopus
  2. G. D. Rubenfeld and M. S. Herridge, “Epidemiology and outcomes of acute lung injury,” CHEST, vol. 131, no. 2, pp. 554–562, 2007. View at Publisher · View at Google Scholar · View at Scopus
  3. M. A. Matthay and G. A. Zimmerman, “Acute lung injury and the acute respiratory distress syndrome: Four decades of inquiry into pathogenesis and rational management,” American Journal of Respiratory Cell and Molecular Biology, vol. 33, no. 4, pp. 319–327, 2005. View at Publisher · View at Google Scholar · View at Scopus
  4. L. He, J. Zheng, L. Xia et al., “Research advances of the role of inflammatory responses in ARDS,” Chinese Critical Care Medicine, vol. 29, no. 7, pp. 651–655, 2017. View at Google Scholar
  5. A. E. Williams and R. C. Chambers, “The mercurial nature of neutrophils: still an enigma in ARDS?” American Journal of Physiology-Lung Cellular and Molecular Physiology, vol. 306, no. 3, pp. L217–L230, 2014. View at Publisher · View at Google Scholar · View at Scopus
  6. V. Fanelli and V. M. Ranieri, “Mechanisms and clinical consequences of acute lung injury,” Annals of the American Thoracic Society, vol. 12, pp. S3–S8, 2015. View at Publisher · View at Google Scholar · View at Scopus
  7. R. E. Dechert, C. F. Haas, and W. Ostwani, “Current Knowledge of Acute Lung Injury and Acute Respiratory Distress Syndrome,” Critical Care Nursing Clinics of North America, vol. 24, no. 3, pp. 377–401, 2012. View at Publisher · View at Google Scholar · View at Scopus
  8. Y. Imai, K. Kuba, G. G. Neely et al., “Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury,” Cell, vol. 133, no. 2, pp. 235–249, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. Y. Cao, H. H. Hong, and J. C. Yang, “Effect of qidong huoxue decoction on inflammatory factors and TLR4 mRNA expression in acute lung injury rats,” Chinese Journal of Traditional Chinese and Western Medicine, vol. 35, no. 4, pp. 438–442, 2015. View at Google Scholar
  10. H. H. Hong, J. C. Yang, R. D. Gao et al., “The effect of qidong huoxue decoction on TLR4/NF-κB inflammatory signaling pathway in acute lung injury rats,” Journal of Wenzhou Medical University, vol. 45, no. 5, pp. 332–337, 2015. View at Google Scholar
  11. H. H. Hong and W. R. Cai, “Effects of qidong huoxue decoction on caveolin-1 and cytokines in acute lung injury rats,” Zhejiang Journal of Integrated Traditional Chinese and Western Medicine, vol. 25, no. 5, pp. 431–435, 2015. View at Google Scholar
  12. Y. Jin, S.-J. Lee, R. D. Minshall, and A. M. K. Choi, “Caveolin-1: A critical regulator of lung injury,” American Journal of Physiology-Lung Cellular and Molecular Physiology, vol. 300, no. 2, pp. L151–L160, 2011. View at Publisher · View at Google Scholar · View at Scopus
  13. E. Abraham, “Neutrophils and acute lung injury,” Critical Care Medicine, vol. 31, no. 4, supplement, pp. S195–S199, 2003. View at Publisher · View at Google Scholar · View at Scopus
  14. K. Chen, T. Eddens, G. Trevejo-Nunez et al., “IL-17 Receptor Signaling in the Lung Epithelium Is Required for Mucosal Chemokine Gradients and Pulmonary Host Defense against K. pneumoniae,” Cell Host & Microbe, vol. 20, no. 5, pp. 596–605, 2016. View at Publisher · View at Google Scholar · View at Scopus
  15. M. Bhatia and S. Moochhala, “Role of inflammatory mediators in the pathophysiology of acute respiratory distress syndrome,” The Journal of Pathology, vol. 202, no. 2, pp. 145–156, 2004. View at Publisher · View at Google Scholar · View at Scopus
  16. P. Puneet, S. Moochhala, and M. Bhatia, “Chemokines in acute respiratory distress syndrome,” American Journal of Physiology-Lung Cellular and Molecular Physiology, vol. 288, no. 1, pp. L3–L15, 2005. View at Publisher · View at Google Scholar · View at Scopus
  17. G. Balamayooran, S. Batra, M. B. Fessler, K. I. Happel, and S. Jeyaseelan, “Mechanisms of neutrophil accumulation in the lungs against bacteria,” American Journal of Respiratory Cell and Molecular Biology, vol. 43, no. 1, pp. 5–16, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. A. Mantovani, M. A. Cassatella, C. Costantini, and S. Jaillon, “Neutrophils in the activation and regulation of innate and adaptive immunity,” Nature Reviews Immunology, vol. 11, no. 8, pp. 519–531, 2011. View at Publisher · View at Google Scholar · View at Scopus
  19. R. Nakamura, N. Maeda, K. Shibata, H. Yamada, T. Kase, and Y. Yoshikai, “Interleukin-15 is critical in the pathogenesis of influenza a virus-induced acute lung injury,” Journal of Virology, vol. 84, no. 11, pp. 5574–5582, 2010. View at Publisher · View at Google Scholar · View at Scopus
  20. J. Xu, J. Guardado, R. Hoffman et al., “IL33-mediated ILC2 activation and neutrophil IL5 production in the lung response after severe trauma: A reverse translation study from a human cohort to a mouse trauma model,” PLoS Medicine, vol. 14, no. 7, Article ID e1002365, 2017. View at Publisher · View at Google Scholar · View at Scopus
  21. K. Takeda, T. Kaisho, and S. Akira, “Toll-like receptors,” Annual Review of Immunology, vol. 21, pp. 335–376, 2003. View at Publisher · View at Google Scholar · View at Scopus
  22. G. M. Barton and R. Medzhitov, “Toll-like receptor signaling pathways,” Science, vol. 300, no. 5625, pp. 1524-1525, 2003. View at Publisher · View at Google Scholar · View at Scopus
  23. C. Huang, K. Jacobson, and M. D. Schaller, “MAP kinases and cell migration,” Journal of Cell Science, vol. 117, part 20, pp. 4619–4628, 2004. View at Publisher · View at Google Scholar · View at Scopus
  24. J. Lu, Z. Yang, J. Jiang, Z. Wang, and P. Zhu, “Regulative effect of p38MAPK on release of TNF alpha and NO from alveolar macrophages under endotoxin stimulation,” Chinese Journal of Traumatology, vol. 4, no. 2, pp. 75–77, 2001. View at Google Scholar
  25. Y. T. Ip and R. J. Davis, “Signal transduction by the c-Jun N-terminal kinase (JNK)—from inflammation to development,” Current Opinion in Cell Biology, vol. 10, no. 2, pp. 205–219, 1998. View at Publisher · View at Google Scholar · View at Scopus
  26. D. Zhang, L. Chen, S. Li, Z. Gu, and J. Yan, “Lipopolysaccharide (LPS) of Porphyromonas gingivalis induces IL-1β, TNF-α and IL-6 production by THP-1 cells in a way different from that of Escherichia coli LPS,” Journal of Innate Immunity, vol. 14, no. 2, pp. 99–107, 2008. View at Publisher · View at Google Scholar · View at Scopus
  27. J.-N. Dai, Y. Zong, L.-M. Zhong et al., “Gastrodin inhibits expression of inducible no synthase, cyclooxygenase-2 and proinflammatory cytokines in cultured LPS-stimulated microglia via MAPK pathways,” PLoS ONE, vol. 6, no. 7, Article ID e21891, 2011. View at Publisher · View at Google Scholar · View at Scopus
  28. J.-Y. Zhang, H. Jin, G.-F. Wang et al., “Methyl-1-hydroxy-2-naphthoate, a novel naphthol derivative, inhibits lipopolysaccharide-induced inflammatory response in macrophages via suppression of NF-κB, JNK and p38 MAPK pathways,” Inflammation Research, vol. 60, no. 9, pp. 851–859, 2011. View at Publisher · View at Google Scholar · View at Scopus
  29. M. Uesugi, K. Nakajima, Y. Tohyama, S. Kohsaka, and T. Kurihara, “Nonparticipation of nuclear factor kappa B (NFkappaB) in the signaling cascade of c-Jun N-terminal kinase (JNK)- and p38 mitogen-activated protein kinase (p38MAPK)-dependent tumor necrosis factor alpha (TNFalpha) induction in lipopolysaccharide (LPS)-stimulated microglia,” Brain Research, vol. 48, no. 12, pp. 1073-1074, 2006. View at Publisher · View at Google Scholar · View at Scopus
  30. T. Fujimoto, H. Kogo, R. Nomura, and T. Une, “Isoforms of caveolin-1 and caveolar structure,” Journal of Cell Science, vol. 113, no. 19, pp. 3509–3517, 2000. View at Google Scholar · View at Scopus
  31. B. Razani, J. A. Engelman, X. B. Wang et al., “Caveolin-1 Null Mice Are Viable but Show Evidence of Hyperproliferative and Vascular Abnormalities,” The Journal of Biological Chemistry, vol. 276, no. 41, pp. 38121–38138, 2001. View at Google Scholar · View at Scopus
  32. S. Garrean, X.-P. Gao, V. Brovkovych et al., “Caveolin-1 regulates NF-κB activation and lung inflammatory response to sepsis induced by lipopolysaccharide,” The Journal of Immunology, vol. 177, no. 7, pp. 4853–4860, 2006. View at Publisher · View at Google Scholar · View at Scopus
  33. Y. Jin, P. K. Hong, M. Chi, E. Ifedigbo, S. W. Ryter, and A. M. K. Choi, “Deletion of caveolin-1 protects against oxidative lung injury via up-regulation of heme oxygenase-1,” American Journal of Respiratory Cell and Molecular Biology, vol. 39, no. 2, pp. 171–179, 2008. View at Publisher · View at Google Scholar · View at Scopus
  34. M. Zhang, L. Lin, S.-J. Lee et al., “Deletion of caveolin-1 protects hyperoxia-induced apoptosis via survivin-mediated pathways,” American Journal of Physiology-Lung Cellular and Molecular Physiology, vol. 297, no. 5, pp. L945–L953, 2009. View at Publisher · View at Google Scholar · View at Scopus
  35. X. M. Wang, H. P. Kim, K. Nakahira, S. W. Ryter, and A. M. K. Choi, “The heme oxygenase-1/carbon monoxide pathway suppresses TLR4 signaling by regulating the interaction of TLR4 with caveolin-1,” The Journal of Immunology, vol. 182, no. 6, pp. 3809–3818, 2009. View at Publisher · View at Google Scholar · View at Scopus
  36. X. M. Wang, H. P. Kim, R. Song, and A. M. K. Choi, “Caveolin-1 confers antiinflammatory effects in murine macrophages via the MKK3/p38 MAPK pathway,” American Journal of Respiratory Cell and Molecular Biology, vol. 34, no. 4, pp. 434–442, 2006. View at Publisher · View at Google Scholar · View at Scopus
  37. X.-J. Lv, Y.-Y. Li, Y.-J. Zhang, M. Mao, and G.-S. Qian, “Over-expression of caveolin-1 aggravate LPS-induced inflammatory response in AT-1 cells via up-regulation of cPLA2/p38 MAPK,” Inflammation Research, vol. 59, no. 7, pp. 531–541, 2010. View at Publisher · View at Google Scholar · View at Scopus
  38. M. K. Mirza, J. Yuan, X.-P. Gao et al., “Caveolin-1 deficiency dampens toll-like receptor 4 signaling through eNOS activation,” The American Journal of Pathology, vol. 176, no. 5, pp. 2344–2351, 2010. View at Publisher · View at Google Scholar · View at Scopus