QiDiTangShen Granules Reduced Diabetic Kidney Injury by Regulating the Phosphorylation Balance of the Tyrosine and Serine Residues of Insulin Receptor Substrate 1

Figure 4

QDTS granules promoted the activation of PI3K/Akt signaling pathway in the kidney of the db/db mice. (a) Expression of PI3K. (b) Expression of phosphorylated PI3K. (c) Expression of Akt. (d) Expression of phosphorylated Akt. (e) Western blot of the expression of PI3K, phosphorylated PI3K, Akt, and phosphorylated Akt. Lane 1, the C57BL/6 group; Lane 2, the db/db model group; Lane 3, the db/db + v group; Lane 4, the db/db + Q group. C57BL/6, the normal control group; db/db, the diabetic nephropathy (DN) model group; db/db + v, the valsartan intervention group; db/db + Q, the QDTS granules intervention group. n = 4 for each group. P < 0.05 compared with the normal control, P < 0.01 compared with the normal control, P < 0.05 compared with the DN model group, and P < 0.01 compared with the DN model group.

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