QiDiTangShen Granules Reduced Diabetic Kidney Injury by Regulating the Phosphorylation Balance of the Tyrosine and Serine Residues of Insulin Receptor Substrate 1

Figure 6

QDTS granules attenuated the activation of the MAPK signaling pathway in the kidney of the db/db mice. (a) Expression of ERK. (b) Expression of phosphorylated ERK. (c) Expression of p38MAPK. (d) Expression of phosphorylated p38MAPK. (e) Expression of JNK. (f) Expression of phosphorylated JNK. (g) Western blot of the expression of EPK, phosphorylated ERK, p38MAPK, phosphorylated p38MAPK, JNK, and phosphorylated JNK. Lane 1, the C57BL/6 group; Lane 2, the db/db model group; Lane 3, the db/db + v group; Lane 4, the db/db + Q group. C57BL/6, the normal control group; db/db, the diabetic nephropathy (DN) model group; db/db + v, the valsartan intervention group; db/db + Q, the QDTS granules intervention group. n = 4 for each group. P < 0.01 compared with the normal control, P < 0.05 compared with the DN model group, and P < 0.01 compared with the DN model group.

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