The Effect of Berberine on Polycystic Ovary Syndrome Patients with Insulin Resistance (PCOS-IR): A Meta-Analysis and Systematic Review

Table 4

The result of meta-analysis regarding the effect of MET+BBR versus MET.

Indices	SMD	95CI	P	Trials involved
BMI^◆4♣4	-0.670^◥☆	-1.927~0.587	0.296^◎	No. 4, No. 5
FSH	-0.025^◤☆	-0.357~0.306	0.880^◎	No. 4, No. 5
LH^◆4♣4	-0.663^◤☆	-0.974~-0.293	0.001	No. 4, No. 5
LH/FSH^◆4♣4	-0.763^◤☆	-1.108~-0.419	0.001	No. 4, No. 5
T^◆4♣4	-0.629^◤☆	-0.969~-0.290	0.001	No. 4, No. 5
HOMA-IR^◆4♣4	-1.113^◥☆	-2.516~0.289	0.120^◎	No. 4, No. 5

Notes:
significant statistical difference (P<0.05) between final value and baseline in MET+BBR group was reported by trial No. x.
significant statistical difference (P<0.05) between final value and baseline in MET group was reported by trial No. x.
Statistical difference between final value and baseline in each group was not reported in trial No. 5.
^◤:fixed effect model;^◥:random effect model.
^◎: P>0.05; : P<0.001.
^☆: MET+BBR group showed a greater change than MET before and after treatment.