Tetrahydroxystilbene Glucoside (TSG) Restores the Effect of Transient Hypoxia on Reperfusion Injury in Senescent H9c2 Cells by Regulating Mitochondrial Energy Metabolism

Figure 3

TSG restored protective effect of transient hypoxia (TH) on senescent H9c2 cells against HR injury by regulating ketone body metabolism. (a, b) The concentration of β-hydroxybutyrate (BHB) and acetoacetate (ACAC)in cell extractions. Data (n=3) were presented as mean ± SEM, p<0.05, p<0.01, p<0.001. (c) mRNA levels of OXCT1 and ACAT1 were quantified by real-time RT-PCR. Data (n=3) were presented as mean ± SEM. OXCT1: p<0.05 and p<0.01; ACAT1: . (d) The concentration of acetyl CoA in cell extractions. Data (n=3) were presented as mean ± SEM, p<0.05, p<0.01 and p<0.001.

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