SYKT Alleviates Doxorubicin-Induced Cardiotoxicity via Modulating ROS-Mediated p53 and MAPK Signal Pathways

<div>Effects of SYKT on DOX-induced cardiomyocyte apoptosis-related proteins at 8 h after DOX processing. (a) The Bax levels were analyzed in the mitochondrial extracts by immunoblotting. (b) Effects of DOX and SYKT on cytoplasmic cytochrome c release in cardiomyocytes. (c) Western blotting analysis of the effects of DOX, SYKT, and DOX+SYKT on caspase-3 activation and PARP cleavage in cardiomyocytes. <i>β</i>-Actin was used as the internal control, and Prohibitin was used as a mitochondrial marker.</div>

Evidence-Based Complementary and Alternative Medicine

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Figure 5

Figure 5: SYKT Alleviates Doxorubicin-Induced Cardiotoxicity via Modulating ROS-Mediated p53 and MAPK Signal Pathways 