Electroacupuncture Alleviates Pain Responses and Inflammation in a Rat Model of Acute Gout Arthritis

Figure 2

Evaluation of different frequencies of EA in treating mechanical hyperalgesia of MSU-induced acute gout arthritis. (a) Experimental scheme of EA or Sham EA treatment on MSU or Veh group rats. Rats were treated with saline (Veh) or MSU on 0 h to establish the gout model. PWT was quantified at 0, 4, 8, 24, and 48 h. EA or Sham EA was applied to MSU-treated rats 30 min before 8, 24, and 48 h observation time point. (b, d and f) Time courses of the effects of 2, 100, or 2/100 Hz EA on mechanical hyperalgesia of the rat gout model. (c, e, and g) Normalized area under the curve (AUC) of panels (b), (d), and (f) (from 0 to 48 h). AUCs were normalized to corresponding Veh group. versus Veh group. , and NS: not significant versus MSU + Sham EA group. –10 rats/group.

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