Efficacy and Safety of Tripterygium Wilfordii Hook F on Psoriasis Vulgaris: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Table 1

Description of studies.

Publication	Sample size; (intervention : control)	Age (mean (SD) or range); (intervention : control)	Intervention	Control	Duration	Outcome	Results
Liu and Tian 2017 [15]	40 : 40	-	Tripterygium glycosides 20 mg tid; acitretin capsules 20 mg once daily	Acitretin capsules 20 mg once daily	8 weeks	PASI 60	82.5%; 45%;
Wang 2017 [10]	40 : 40	39.28 ± 4.51; 39. 98 ± 5.03	Tripterygium glycosides 20 mg tid; compound glycyrrhizin 50 mg tid	Compound glycyrrhizin 50 mg tid	8 weeks	PASI 60	77.5%; 52.5%;
Fan 2016 [21]	98 : 98	30.4 ± 6.5 : 31.2 ± 6.8	Tripterygium glycosides 20 mg tid; 0.05% tazarotene gel once daily	0.05% tazarotene gel once daily	3 months	75% reduction rate	33.67%: 33.69%:
Guan 2016 [16]	43 : 43	36.9 ± 7.6 : 36.8 ± 7.8	Tripterygium glycosides 10 mg tid; acitretin capsules 30 mg once daily	Acitretin capsules 30 mg once daily	8 weeks	PASI 60	72.1%: 58.1%;
Liu 2015 [8]	55; 55	31.2 ± 6.4; 32.1 ± 5.8	Tripterygium glycosides 20 mg tid;	Cyclosporin A 2.5 mg/kg/day; after 4 weeks, increase dose to 3–5 mg/kg/day	12 weeks	PASI 60	63.6%; 47.3%;
Wu 2015 [5]	58 : 57	42.0 ± 12.0 : 40.2 ± 12.4	Tripterygium glycosides 20 mg tid; placebo matching acitretin 30 mg once daily	Acitretin 30 mg once daily; placebo matching TwHF 20 mg tid	8 weeks	PASI 75	19.0%; 17.5%;
Zhou 2015 [11]	34 : 33	36.2 ± 4.7; 35.9 ± 5.3	Tripterygium glycosides 20 mg tid; compound glycyrrhizin 400 mL injection once daily	Compound glycyrrhizin 400 mL injection once daily	2 months	PASI 30	97.1%; 81.8%;
Liu 2014 [12]	40 : 40	-	Tripterygium glycosides 20 mg tid; compound glycyrrhizin 60 mL injection once daily	Compound glycyrrhizin 60 mL injection once daily	4 weeks	PASI 60	75%; 57.5%;
Kong 2013 [13]	100 : 100	32.78 ± 18.21 : 31.5 ± 17.23	Tripterygium glycosides 20 mg tid; compound glycyrrhizin 60 mL injection once daily	Compound glycyrrhizin 60 mL injection once daily	4 weeks	PASI 60	84%; 56%;
Zhao 2012 [14]	45 : 40	36.5 ± 4.4 : 35.5 ± 5.1	Tripterygium glycosides 20 mg tid; compound glycyrrhizin 40 mL injection once daily	Compound glycyrrhizin 40 mL injection once daily	8 weeks	30% reduction rate	75.6%; 60.0%;
Zhou and Ke 2012 [22]	60 : 60	36.58 ± 4.92 : 37.12 ± 4.32	Tripterygium glycosides 20 mg tid for first 4 weeks and 10 mg tid for last 4 weeks; NB-UVB 3 times per week	NB-UVB 3 times per week	8 weeks	PASI 60	88.33%; 63.33%;
Qi et al. 2009 [9]	48 : 47	-	TwHF 20 mg tid;	Compound glycyrrhizin 60 mL injection once daily	8 weeks	PASI 60	81.25%; 76.60%;
Qiu et al. 2009 [23]	52 : 50	-	Tripterygium glycosides 20 mg tid; Chinese medicine Fuling decoction once daily	Compound Qingdai pills 6 g tid	3 months	60% reduction rate	90.4%; 56.0%
He 2008 [17]	19 : 20	34.3 ± 10.1 : 35.5 ± 14.3	Tripterygium glycosides 20 mg tid; acitretin capsules 0.5–1 mg/kg⋅d bid or tid	Acitretin capsules 0.5–1 mg/kg⋅d bid or tid	8 weeks	PASI 60	84.2%; 38.9%;
Y. Liu and J. Liu 2007 [24]	36 : 34	33.5 : 35.8	Tripterygium glycosides 10–20 mg tid; Chinese medicine Xiaoyin decoction once daily	Compound Qingdai pills 6  day^−1	4 weeks	PASI 70	86.1%; 64.7%
Feng 2004 [18]	56 : 33	-	Tripterygium glycosides 20 mg tid; compound amino-polypeptide Tablets 5 pieces bid	Compound amino-polypeptide tablets 5 pieces bid	10 weeks	PASI 60	76.78%; 57.57%
Huang 2004 [19]	52 : 43	36.7 ± 18.2 : 34.7 ± 19.3	Tripterygium glycosides 10 mg tid; Compound Amino-polypeptide tablets 5 pieces bid	Compound amino-polypeptide tablets 5 pieces bid	60 days	PASI 60	71.15%; 46.51%
Hou 2001 [20]	43 : 35	31.4 : 33.2	Tripterygium glycosides 20 mg tid + compound amino-polypeptide tablets 5 pieces bid	Compound amino-polypeptide tablets 5 pieces bid	30 days	PASI 60	81.4%; 60.0%;
Ma 2000 [6]	50 : 50	28 ± 2.3 : 29.54 ± 13.22	Tripterygium glycosides capsules 6 g tid	Qingdai capsules 6 g tid	4 weeks	PASI 70	84%; 84%;
Zhang 1999 [7]	25 : 27	26.68 ± 12.3 : 28.62 ± 14.23	Tripterygium glycosides capsules 6 g tid	Placebo capsules 6 g tid	4 weeks	PASI 70	84%; 11.11%