|
| Publication | Adverse events (number) | AE rate (%) |
| Intervention group | Control group | Intervention group | Control group |
|
| Liu and Tian 2017 [15] | Mouth dryness and anorexia (1) | Gastrointestinal reactions (2) | 2.5% | 2.5%. |
| Wang 2017 [10] | No AEs | No AEs | 0% | 0% |
| Fan 2016 [21] | Not mentioned | Not mentioned | - | - |
| Guan 2016 [16] | Gastrointestinal reactions (2), mouth or skin dryness (11) | Gastrointestinal reactions (3) Mouth or skin dryness (11) | 32.6% | 32.2% |
| Liu 2015 [8] | Anorexia (1), diarrhea (2), menstrual disorders in females (2) | Serum creatinine and urea nitrogen increased (4); Anorexia (2) Diarrhea (1) | 9.1% | 12.7% |
| Wu et al. 2015 [5] | Menstrual disorders in females, dry mouth, gastrointestinal reactions, and swelling of the lower limbs (undefined) | Dry mucosa, facial pigmentation, hair loss, paronychia, palpitation (undefined) | 43.6% | 78.1% |
| Zhou 2015 [11] | Anorexia (1), diarrhea (2), menstrual disorders in females (2) | Serum creatinine and urea nitrogen increased (4); Anorexia (2) Diarrhea (1) | 9.1% | 12.7% |
| Liu 2014 [12] | Nausea (1) | Anorexia (1); Serum creatinine increased (1) | 2.9% | 6.1% |
| Kong 2013 [13] | Not AEs | Not AEs | 0% | 0% |
| Zhao 2012 [14] | Not mentioned | Not mentioned | - | - |
| Zhou and Ke 2012 [22] | Skin dry or pain (2), gastrointestinal reactions (8), hepatocytes abnormal (1), routine blood abnormal (2) | Skin dry or pain (4) | 21.67% | 6.7% |
| Qi et al. 2009 [9] | Serum creatinine increased (2) | Not AEs | 4.26% | 0% |
| Qiu 2009 [23] | Not mentioned | Not mentioned | - | - |
| He 2008 [17] | Menstrual disorders in females (2), routine blood abnormal (1) | Dry mucosa or skin or eyes (12), hair loss (1) | 15.79% | 65% |
| Y. Liu and J. Liu 2007 [24] | Gastrointestinal reactions (1) | Not AEs | 2.78% | 0% |
| Feng and Zhang 2004 [18] | Not mentioned | Not mentioned | - | - |
| Huang et al. 2004 [19] | Skin dry or pain (14), gastrointestinal reactions (3), hepatocytes abnormal (1), routine blood abnormal (2) | Skin dry or pain (12). | 38.46% | 27.91% |
| Hou et al. 2001 [20] | Mouth or skin dry, gastrointestinal reactions (29) | Mouth dryness (23) | 67.44% | 65.71% |
| Ma et al. 2000 [6] | Menstrual disorders in females (1), gastrointestinal reactions (2) | Gastrointestinal reactions (undefined) | 6% | - |
| Zhang et al. 1999 [7] | Menstrual disorders in females (1), gastrointestinal reactions (6) | Not AEs | 28% | 0% |
|
