Nutmeg Extract Increases Skeletal Muscle Mass in Aging Rats Partly via IGF1-AKT-mTOR Pathway and Inhibition of Autophagy

Figure 3

Nutmeg increases gene expression of Pax7, MyoD, myogenin, MHCI, and IGF1 in soleus muscle. Data represent ratio in mean ± SEM of experiment. p <0.01 compared with control group. Increasing Pax7 and MyoD gene expression shows that there is muscle growth and regeneration occurring after 12-week nutmeg extract treatment on aging rats. Increasing another gene related to muscle cell fusion, myogenin (p <0.01) supports another result that nutmeg stimulates muscle growth. To more support the result and the pathway involving, observation from gene related to fiber marker MHC1 also increased (p<0.01) and also genes have pivotal role in protein synthesis muscle hypertrophy IGF1 (p<0.01).