Gastroprotective Mechanism and Ulcer Resolution Effect of Cyrtocarpa procera Methanolic Extract on Ethanol-Induced Gastric Injury

Figure 7

CpMet treatment. Mice stomach treated with CpMet (300 mg/kg twice a day) on the 20th day after GU induction. (a) Macroscopic view of a formalin fixed stomach mainly showing a smooth surface with few flat small scars (dashed box). (b), (c), and (d) Bright-field microscopic views of 5 μm thickness sagittal sections of the glandular portion of the stomach, stained with PAS. (b) Panoramic histopathological appearance revealing a good organization of the basal gastric mucosa architecture with only minor alterations at the apical portion of the mucosa and abundant PAS-positive clusters lining the epithelium. Dashed boxes: left, magnification to show mucus presence; right, histopathological status of the tissue. (c) Histopathological observation displaying well-organized mucosal architecture, no inflammatory infiltrates are observed. (d) Gastric mucosa with strong PAS positivity surrounding the epithelium and areas of expanded mucous neck cells secreting increased amounts of mucins. Normal and well-defined mucous producing cells are observed.