Chronic Unpredictable Mild Stress Aggravates Mood Disorder, Cognitive Impairment, and Brain Insulin Resistance in Diabetic Rat

Figure 2

Characterization of diabetic rats with CUMS. High-fat diet and streptozotocin injection induces changes in fasting blood glucose levels, HbA1c levels, insulin resistance index, and oral glucose tolerance test. After receiving CUMS, there were no obvious changes in the above indexes of the diabetic rats. (a) Oral glucose tolerance test. (b) Area under curve of the glucose level in oral glucose tolerance test. (c) The level of HbA1c. (d) Fasting blood glucose concentration. (e) Fasting insulin concentration. (f) Insulin resistance index. (g) The level of leptin. p<0.01, control versus diabetic.

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