Antimycobacterial Activity and Safety Profile Assessment of Alpinia galanga and Tinospora cordifolia
Table 4
Effect of the extracts on haematological parameters of mice in chronic toxicity test.
Parameters
Extracts
Control
AGDC
%
AGET
%
TCDC
%
TCET
%
166 mg/kg
change
193 mg/kg
change
189 mg/kg
change
170 mg/kg
change
RBC (x 106/mm3)
7.8 ± 0.12
6.80 ± 0.12
13↓
6.35 ± 0.15
18↓
7.00 ± 0.20
10↓
6.92 ± 0.08
11↓
WBC (x 103/mm3)
9.10 ± 0.17
8.45 ± 0.06
7↓
6.97 ± 0.11
23↓
9.17 ± 0.12
-
7.77 ± 0.19
15↓
Hemoglobin (g/dl)
11.75 ± 0.19
11.0 ± 0.20
6↓
9.05 ± 0.19
23↓
11.45 ± 0.42
2↓
10.32 ± 0.19
12↓
Platelets( x 103/mL)
276.7 ± 4.32
263.0 ± 3.24
5↓
244.7 ± 3.37
12↓
255.0 ± 2.58
8↓
260.25 ± 2.68
6↓
Neutrophils (x 103/mm3)
3.70 ± 0.09
3.15 ± 0.14
15↓
3.35 ± 0.06
9↓
3.45 ± 0.15
7↓
3.30 ± 0.25
11↓
Lymphocytes ( x 103/mm3)
5.95 ± 0.11
5.52 ± 0.23
7↓
5.67 ± 0.18
5↓
5.37 ± 0.25
10↓
4.87 ± 0.12
18↓
All values represent mean ± SEM. p < 0.05; p < 0.01; p < 0.001; ANOVA, followed by Dunnett’s multiple comparison test. Test value compared with control group
