The Therapeutic Effects of a Traditional Chinese Medicine Formula Wuzi Yanzong Pill for the Treatment of Oligoasthenozoospermia: A Meta-Analysis of Randomized Controlled Trials

Table 1

Characteristics of included studies.

Author

Year

Region

Treatment duration

Interventions

Participants number

Mean age

Baseline comparable

Methods

Reported sperm parameters

Con

Mot

Mph

Acr

Vol

DFI

Yao and Chen

2015

SC

3 months

K versus W versus P

110 (40/40/30)

31.25/32.11/31.74

√

CASA

√

√

√

√

X

√

Zhang et al.

2017

NEC

3 months

G versus W versus P

84 (32/26/26)

29.4/29.6/28.3

√

CASA

√

√

√

√

√

X

Zhang

2017

SC

3 months

W versus V

580 (300/280)

30.9/31.1

√

Manual

√

√

X

X

X

√

Li

2013

SC

3 months

W versus V

120 (60/60)

29.9/30.8

√

Manual

√

√

X

X

X

X

Wang et al.

2010

SC

3 months

W versus V

138 (83/55)

30.3/32.4

√

Manual

√

√

X

X

√

X

Con = Sperm Concentration; Mot = Sperm Motility; Mph = Sperm Mophorlogy; Acr = Activity of Acrosomal Enzyme; DFI = DNA Fragmentation Index; SC = South China; NEC = North-east China; W = Wuzi Yanzong pill; P = Placebo; V = Vitamin control; K = Kidney Essence Granule; G = Gonadotropins; CASA = computer-assisted semen analysis; Asterisk means the study only reported Grade A parameters of sperm motility.