Antidiarrheal Activity of 80% Methanolic Leaf Extract of Justicia schimperiana

Table 2

In vivo antidiarrheal index of the methanolic leaf extract of J. schimperiana.

Group	Dose; (mg/kg)	Delay in diarrhea onset ( freq)	Charcoal meal travel reduction ( meq)	Reduction in the number of wet stools ( freq)	In vivo ADI
Group 1 (negative control)	-	-	-	-	-
Group 2 (positive control)	-	206.06	48.06	80.06	92.55
Group 3 (extract)	100	19.95	3.15	42.58	13.88
Group 4 (extract	200	36.36	25.42	65.07	39.18
Group 5 (extract)	400	96.97	35.95	74.96	63.93

Negative control: a group of mice that received distilled water. Positive control: a group of mice treated with loperamide (3 mg/kg) in a castor oil-induced diarrhea model and atropine (1 mg/kg) in a gastrointestinal motility test model.