Zanthoxylum ailanthoides Suppresses Oleic Acid-Induced Lipid Accumulation through an Activation of LKB1/AMPK Pathway in HepG2 Cells

Figure 4

ZA-M activates the LKB1/AMPK signaling pathway. (a, b) Western blot analysis of phosphorylation status of AMPK (Thr 172) and ACC (Ser 79) after treatment of indicated concentrations of ZA-M (50, 30, and 10 μg/ml) in the present or absent of OA in HepG2 cells. (c) AMPK kinase activity. (d) Western blot analysis of phosphorylation status of LKB-1 after treatment of indicated concentrations of ZA-M (50, 30, and 10 μg/ml) in the present in HepG2 cells. The bar graphs show the mean ± SD of 3 independent experiments ( and compared with the DMSO control; compared with the OA treated control).

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