Research Article

Astragaloside Inhibits Hepatic Fibrosis by Modulation of TGF-β1/Smad Signaling Pathway

Figure 2

Effects of astragalosides on ECM factors in HSC induced by TGF-β1. By assay of ELISA, AST was found to inhibit collagen accumulation and the expression of MMP-2 and TIMP-2 (a), and the results of real-time PCR showed the same trend (b). AST: astragalosides; LY-364947: TGF-β receptor 1 inhibitor. The values presented are the means ± SD ( in each group). and versus control group; and versus model group (TGF-β1).
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(b)