Astragaloside Inhibits Hepatic Fibrosis by Modulation of TGF-β1/Smad Signaling Pathway

Figure 4

Inhibitory effects of AST on collage deposition and liver damage induced by CCL4 in rats. (a) The pathological features of liver tissue in each group were evaluated by H&E (×400), and collagen deposition was visualized by Masson’s trichrome staining and Sirius red staining (×400) (b-c). AST was found to alleviate hepatic collagen accumulation and damage induced by CCL4. (d) Levels of ALT, AST, TBiL, and Alb in serum were detected by ELISA; AST was found to alleviate hepatic damage induced by CCL4 in a dose-dependent manner. (e) Hepatic fibrosis was evaluated by hydroxyproline content; AST was found to reduce the content of hydroxyproline by assay of ELISA. AST: astragalosides; LY-364947: TGF-β receptor 1 inhibitor. The values presented are the means ± SD ( in each group). and versus control group; and versus model group (CCL4).

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