Astragaloside Inhibits Hepatic Fibrosis by Modulation of TGF-<i>β</i>1/Smad Signaling Pathway

<div>Effects of astragalosides on the mRNA expression of TGF-<i>β</i>1/Smad signaling pathway components in rats. The expression of TGF-<i>β</i>1, T<i>β</i>R-I, Smad 2, Smad 3, and Smad 7 mRNA was analyzed by real-time PCR, <i>β</i>-actin served as control, and the results were expressed as <span class="nowrap"><svg height="11.97pt" id="M60" style="vertical-align:-0.04979992pt" version="1.1" viewbox="-0.0498162 -11.9202 33.2495 11.97" width="33.2495pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M412 140C382 77 369 73 315 73H129L270 222C362 320 402 379 402 466C402 571 322 635 234 635C177 635 130 609 99 576L42 495L64 475C90 514 133 568 201 568C274 568 318 519 318 435C318 349 255 267 193 193C144 135 87 78 32 23V0H405C417 45 427 89 440 131L412 140Z" id="g113-51"></path></g><g transform="matrix(.0091,0,0,-0.0091,6.24,-5.741)"><path d="M556 236V289H56V236H556Z" id="g54-33"></path></g><g transform="matrix(.0091,0,0,-0.0091,11.8,-5.741)"><path d="M610 0V27L347 666L316 657L46 26V0H610ZM504 54H116L310 537L504 54Z" id="g50-133"></path></g><g transform="matrix(.0091,0,0,-0.0091,17.747,-5.741)"><path d="M610 0V27L347 666L316 657L46 26V0H610ZM504 54H116L310 537L504 54Z" id="g50-133"></path></g><g transform="matrix(.0091,0,0,-0.0091,23.694,-5.741)"><path d="M618 181C565 77 513 26 413 26C264 26 151 150 151 336C151 486 240 625 407 625C516 625 573 582 600 475L634 483C627 540 622 581 613 638C585 643 518 665 435 665C211 665 46 526 46 315C46 158 157 -15 406 -15C480 -15 564 4 594 12C612 43 638 121 651 168L618 181Z" id="g58-65"></path></g><g transform="matrix(.0091,0,0,-0.0091,29.682,-5.741)"><path d="M303 37L293 66C280 59 256 49 231 49S173 63 173 143V396H281C294 404 298 428 287 439H173V575L158 577L92 509V439H46L17 408L22 396H92V107C92 27 128 -12 192 -12C203 -12 218 -9 237 2L303 37Z" id="g58-114"></path></g></svg>.</span> AST was found to decrease the levels of TGF-<i>β</i>1, T<i>β</i>R-I, Smad 2, and Smad 3 mRNA, while the expression of Smad 7 was enhanced. AST: astragalosides; LY-364947: TGF-<i>β</i> receptor 1 inhibitor. 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Evidence-Based Complementary and Alternative Medicine

fig8

Figure 8

Figure 8: Astragaloside Inhibits Hepatic Fibrosis by Modulation of TGF-<i>β</i>1/Smad Signaling Pathway 

Evidence-Based Complementary and Alternative Medicine

Astragaloside Inhibits Hepatic Fibrosis by Modulation of TGF-β1/Smad Signaling Pathway

Figure 8