Development and Application of an UHPLC-MS/MS Method for Comparative Pharmacokinetic Study of Eight Major Bioactive Components from Yin Chen Hao Tang in Normal and Acute Liver Injured Rats

<table class="figure-group"><tr class="fig-image" id="a"><td><object data="https://static.hindawi.com/articles/ecam/volume-2018/3239785/figures/3239785.fig.003a.svgz" name="3239785.fig.003a" type="image/svg+xml"></object></td></tr><tr class="fig-caption"><td><b>(a) </b>Scoparone</td></tr><tr class="fig-image" id="b"><td><object data="https://static.hindawi.com/articles/ecam/volume-2018/3239785/figures/3239785.fig.003b.svgz" name="3239785.fig.003b" type="image/svg+xml"></object></td></tr><tr class="fig-caption"><td><b>(b) </b>Scopoletin</td></tr><tr class="fig-image" id="c"><td><object data="https://static.hindawi.com/articles/ecam/volume-2018/3239785/figures/3239785.fig.003c.svgz" name="3239785.fig.003c" type="image/svg+xml"></object></td></tr><tr class="fig-caption"><td><b>(c) </b>Geniposide</td></tr><tr class="fig-image" id="d"><td><object data="https://static.hindawi.com/articles/ecam/volume-2018/3239785/figures/3239785.fig.003d.svgz" name="3239785.fig.003d" type="image/svg+xml"></object></td></tr><tr class="fig-caption"><td><b>(d) </b>Rhein</td></tr><tr class="fig-image" id="e"><td><object data="https://static.hindawi.com/articles/ecam/volume-2018/3239785/figures/3239785.fig.003e.svgz" name="3239785.fig.003e" type="image/svg+xml"></object></td></tr><tr class="fig-caption"><td><b>(e) </b>Aloe-emodin</td></tr><tr class="fig-image" id="f"><td><object data="https://static.hindawi.com/articles/ecam/volume-2018/3239785/figures/3239785.fig.003f.svgz" name="3239785.fig.003f" type="image/svg+xml"></object></td></tr><tr class="fig-caption"><td><b>(f) </b>Chrysophanol</td></tr><tr class="fig-image" id="g"><td><object data="https://static.hindawi.com/articles/ecam/volume-2018/3239785/figures/3239785.fig.003g.svgz" name="3239785.fig.003g" type="image/svg+xml"></object></td></tr><tr class="fig-caption"><td><b>(g) </b>Emodin</td></tr><tr class="fig-image" id="h"><td><object data="https://static.hindawi.com/articles/ecam/volume-2018/3239785/figures/3239785.fig.003h.svgz" name="3239785.fig.003h" type="image/svg+xml"></object></td></tr><tr class="fig-caption"><td><b>(h) </b>Physcion</td></tr></table>

<div>Mean concentration-time profiles of (a) scoparone, (b) scopoletin, (c) geniposide, (d) aloe-emodin, (e) rhein, (f) emodin, (g) chrysophanol, and (h) physcion based integrated concentration in control and model rat plasma after oral administration of YCHT (n = 6).</div>

Evidence-Based Complementary and Alternative Medicine

fig3

Figure 3

Figure 3: Development and Application of an UHPLC-MS/MS Method for Comparative Pharmacokinetic Study of Eight Major Bioactive Components from Yin Chen Hao Tang in Normal and Acute Liver Injured Rats 

Figure 3 | Development and Application of an UHPLC-MS/MS Method for Comparative Pharmacokinetic Study of Eight Major Bioactive Components from Yin Chen Hao Tang in Normal and Acute Liver Injured Rats 