Development and Application of an UHPLC-MS/MS Method for Comparative Pharmacokinetic Study of Eight Major Bioactive Components from Yin Chen Hao Tang in Normal and Acute Liver Injured Rats

Table 2

Calibration curves, correlation coefficients, linear ranges, LLOD, and LOQ of eight constituents in rat plasma.

Analytes	Calibration curves	Correlation coefficient (r)	Linearity range (ng mL^−1)	LLOD (ng mL^−1)	LLOQ (ng mL^−1)
Scoparone	=6.732010^−3x+2.713010^−3	0.9984	0.510-2040.0	0.1020	0.5100
Scopoletin	=1.104110^−2x+1.812410^−2	0.9990	0.502-50.2	0.1004	0.5020
Geniposide	=1.767810^−5x+1.160610^−5	0.9985	0.516-2064.0	0.1032	0.5160
Aloe-emodin	=3.572710^−4x-2.000710^−4	0.9987	0.532-106.4	0.1064	0.5320
Rhein	=3.021010^−3x+1.936010^−3	0.9981	0.540-2160.0	0.1080	0.5400
Emodin	=6.873010^−3x+1.479010^−3	0.9995	0.525-52.5	0.1050	0.5250
Chrysophanol	=7.771810^−5x-3.035510^−5	0.9990	0.500-100.0	0.1000	0.5000
Physcion	=9.761510^−5x-5.174210^−5	0.9987	0.512-51.2	0.1024	0.5120