Development and Application of an UHPLC-MS/MS Method for Comparative Pharmacokinetic Study of Eight Major Bioactive Components from Yin Chen Hao Tang in Normal and Acute Liver Injured Rats
Table 3
Pharmacokinetic parameters for eight compounds in plasma after oral administration of YCHT.
Pharmacokinetic Parameter
t1/2 (h)
C (μg/L)
T (h)
AUC (ug/Lh)
AUC (ug/Lh)
MRT (h)
MRT (h)
CLz/F (L/h/kg)
Fr (%)
Scoparone
Control
2.14 ± 0.71
939.32 ± 112.19
0.54 ± 0.10
2282.77 ± 390.03
2347.92 ± 428.69
3.19 ± 0.16
3.51 ± 0.14
4.42 ± 0.82
227.64
Model
1.58 ± 0.13
1767.17 ± 106.78
0.33 ± 0.13
5196.54 ± 513.37
5197.06 ± 513.33
3.94 ± 0.26
3.95 ± 0.26
1.96 ± 0.23
Scopoletin
Control
3.62 ± 3.85
3.53 ± 0.67
0.19 ± 0.04
5.86 ± 0.50
7.41 ± 2.53
4.40 ± 0.44
6.90 ± 4.20
70.72 ± 16.41
123.38
Model
2.20 ± 0.82
3.34 ± 1.19
0.13 ± 0.05
7.23 ± 1.84
7.83 ± 2.00
4.81 ± 0.43
5.56 ± 0.63
66.11 ± 16.51
Geniposide
Control
3.55 ± 0.38
751.37 ± 47.72
0.33 ± 0.13
1940.63 ± 210.72
1958.65 ± 206.96
4.57 ± 0.41
4.80 ± 0.47
8.84 ± 0.92
257.67
Model
6.59 ± 2.46
1863.84 ± 108.53
0.58 ± 0.20
5000.36 ± 755.13
5223.83 ± 746.92
4.68 ± 0.57
5.99 ± 0.61
3.34 ± 0.49
Aloe-emodin
Control
2.26 ± 1.15
15.18 ± 1.68
0.54 ± 0.19
54.61 ± 6.50
60.86 ± 6.68
3.34 ± 0.12
4.33 ± 0.84
44.24 ± 5.84
281.30
Model
1.98 ± 0.71
36.68 ± 3.09
0.58 ± 0.30
153.62 ± 18.13
158.71 ± 19.26
3.68 ± 0.34
4.07 ± 0.40
16.98 ± 2.15
Rhein
Control
4.64 ± 2.14
663.62 ± 50.31
0.33 ± 0.13
2031.40 ± 385.58
2074.39 ± 387.77
4.79 ± 0.36
5.38 ± 0.49
4.92 ± 1.11
268.45
Model
3.62 ± 1.97
1759.02 ± 140.49
0.54 ± 0.19
5453.29 ± 1202.14
5518.78 ± 1256.46
4.38 ± 0.41
4.67 ± 0.65
1.87 ± 0.43
Emodin
Control
3.33 ± 1.67
3.51 ± 0.59
0.20 ± 0.17
10.41 ± 0.83
12.06 ± 1.53
4.94 ± 0.26
6.65 ± 1.99
69.69 ± 8.45
112.01
Model
3.64 ± 0.79
3.89 ± 0.89
0.17 ± 0.05
11.66 ± 2.70
13.49 ± 2.43
4.83 ± 0.25
6.64 ± 0.78
63.22 ± 11.47
Chrysophanol
Control
2.00 ± 0.23
34.48 ± 4.99
0.63 ± 0.26
99.34 ± 10.12
103.57 ± 10.09
2.93 ± 0.16
3.34 ± 0.21
21.80 ± 2.08
142.23
Model
3.12 ± 1.74
37.61 ± 6.51
0.88 ± 0.35
141.29 ± 27.92
148.47 ± 25.04
3.43 ± 0.40
4.20 ± 0.77
15.42 ± 2.38
Physcione
Control
2.65 ± 0.99
8.45 ± 1.61
1.25 ± 0.27
21.05 ± 4.04
22.44 ± 5.54
2.88 ± 0.25
3.54 ± 0.49
26.99 ± 5.66
213.68
Model
3.06 ± 2.37
9.99 ± 2.86
2.58 ± 1.11
44.98 ± 13.92
48.47 ± 12.74
4.07 ± 0.40
5.26 ± 1.30
12.63 ± 3.12
p<0.05 compared with control rats. p<0.01 compared with control rats.
