Bufadienolides from<i> Venenum Bufonis</i> Inhibit mTOR-Mediated Cyclin D1 and Retinoblastoma Protein Leading to Arrest of Cell Cycle in Cancer Cells

<div><b>Bufadienolides inhibit expression of cyclin D1 and phosphorylation of Rb</b>. (a, c) MCF-7 cells were treated with different concentration of bufadienolides (0-10 <i>μ</i>g/ml) for 24 h, then cellular lysates were subjected to western blotting analysis for detecting the indicated protein molecules. (b, d) The same experiment was repeated in DU145 cells.</div>

Evidence-Based Complementary and Alternative Medicine

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Figure 4: Bufadienolides from<i> Venenum Bufonis</i> Inhibit mTOR-Mediated Cyclin D1 and Retinoblastoma Protein Leading to Arrest of Cell Cycle in Cancer Cells 

Figure 4 | Bufadienolides from Venenum Bufonis Inhibit mTOR-Mediated Cyclin D1 and Retinoblastoma Protein Leading to Arrest of Cell Cycle in Cancer Cells 