Zirconium-Porphyrin PCN-222: pH-responsive Controlled Anticancer Drug Oridonin

Table 1

Fitting curve by different mathematical model under different pH values (Rt: accumulated release rate).

	pH=5.5		pH=7.2
	Equation	r^2	Equation	r^2
zero-order	= 0.0047 t + 0.2433	0.811	= 0.0039t + 0.1298	0.850
First-order	Ln(1-Rt) = -0.0118 t - 0.2627	0.944	Ln(1-Rt) = - 0.0065t - 0.1379	0.897
Higuchi	= 0.0679 t^1/2 +0.0874	0.952	Rt= 0.055t^1/2 + 0.0079	0.963
Weibull	lnln[1/(1-)] = 0.6384lnt - 2.4694	0.977	lnln[1/(1-)] = 0.653lnt - 3.1688	0.987
Ritger-Peppas	ln (/) = 0.4862lnt - 2.4274	0.933	ln (/) = 0.5608lnt - 3.1287	0.981