Evidence-Based Complementary and Alternative Medicine / 2018 / Article / Tab 4

Research Article

Antihyperglycemic and Antilipidemic Effects of the Ethanol Extract Mixture of Ligularia fischeri and Momordica charantia in Type II Diabetes-Mimicking Mice

Table 4

Changes in water intake, food intake, and body weight gain in STZ/ATH and db/db/ATH mice.

GroupWater intake (mL/day)Food intake (g/day)Body weight
gain (g)

ICR mice (n = 6 per each group)
Normal control4.5 ± 0.374.6 ± 0.306.4 ± 2.28
STZ/ATH mice (n=6 per each group)
 vehicle13.9 ± 1.38.3 ± 0.63.0 ± 3.14
 MCE (mg/kg/day)
  5011.7 ± 1.12##8.7 ± 0.612.4 ± 1.07
  10010.9 ± 1.39##8.3 ± 0.682.5 ± 0.36
  2009.9 ± 1.36##7.4 ± 1.06##4.0 ± 0.74
 LFE (mg/kg/day)
  5013.8 ± 1.508.2 ± 0.521.8 ± 0.84
  10013.6 ± 1.299.1 ± 0.95#2.4 ± 0.67
  20013.6 ± 1.5310.0 ± 1.62##2.4 ± 0.39
 MLM (mg/kg/day)
  5013.0 ± 1.466.6 ± 1.02##2.6 ± 1.18
  10011.6 ± 1.37##8.2 ± 0.572.8 ± 2.69
  20010.8 ± 1.55##8.4 ± 0.913.1 ± 0.87
db/db/ATH mice (n=5 per each group)
 vehicle11.3 ± 1.645.7 ± 0.8225.2 ± 1.91
 MLM (mg/kg/day)
  5010.7 ± 1.526.4 ± 0.525.0 ± 1.82
  1009.7 ± 1.76.3 ± 0.7222.9 ± 2.77
  2009.2 ± 1.55.3 ± 0.8721.1 ± 3.72

Data are the mean ± SD (each group, n=6). p < 0.05, p < 0.01, vs. the normal control group. #p < 0.05, ##p < 0.01 vs. the STZ/ATH group. ATH, atherogenic diet D12336 (Research Diets, Inc.); MCE, ethanol extract of Momordica charantia fruit; LFE, ethanol extract of Ligularia fischeri leaves; MLM, 8:2 mixture of MCE and LFE; STZ, streptozotocin (100 mg/kg).