Antihyperglycemic and Antilipidemic Effects of the Ethanol Extract Mixture of Ligularia fischeri and Momordica charantia in Type II Diabetes-Mimicking Mice

Table 4

Changes in water intake, food intake, and body weight gain in STZ/ATH and db/db/ATH mice.

Group	Water intake (mL/day)	Food intake (g/day)	Body weight; gain (g)
ICR mice (n = 6 per each group)
Normal control	4.5 ± 0.37	4.6 ± 0.30	6.4 ± 2.28
STZ/ATH mice (n=6 per each group)
vehicle	13.9 ± 1.3	8.3 ± 0.6	3.0 ± 3.14
MCE (mg/kg/day)
50	11.7 ± 1.12^##	8.7 ± 0.61	2.4 ± 1.07
100	10.9 ± 1.39^##	8.3 ± 0.68	2.5 ± 0.36
200	9.9 ± 1.36^##	7.4 ± 1.06^##	4.0 ± 0.74
LFE (mg/kg/day)
50	13.8 ± 1.50	8.2 ± 0.52	1.8 ± 0.84
100	13.6 ± 1.29	9.1 ± 0.95^#	2.4 ± 0.67
200	13.6 ± 1.53	10.0 ± 1.62^##	2.4 ± 0.39
MLM (mg/kg/day)
50	13.0 ± 1.46	6.6 ± 1.02^##	2.6 ± 1.18
100	11.6 ± 1.37^##	8.2 ± 0.57	2.8 ± 2.69
200	10.8 ± 1.55^##	8.4 ± 0.91	3.1 ± 0.87
db/db/ATH mice (n=5 per each group)
vehicle	11.3 ± 1.64	5.7 ± 0.82	25.2 ± 1.91
MLM (mg/kg/day)
50	10.7 ± 1.52	6.4 ± 0.5	25.0 ± 1.82
100	9.7 ± 1.7	6.3 ± 0.72	22.9 ± 2.77
200	9.2 ± 1.5	5.3 ± 0.87	21.1 ± 3.72

Data are the mean ± SD (each group, n=6). p < 0.05, p < 0.01, vs. the normal control group. ^#p < 0.05, ^##p < 0.01 vs. the STZ/ATH group. ATH, atherogenic diet D12336 (Research Diets, Inc.); MCE, ethanol extract of Momordica charantia fruit; LFE, ethanol extract of Ligularia fischeri leaves; MLM, 8:2 mixture of MCE and LFE; STZ, streptozotocin (100 mg/kg).