Antihyperglycemic and Antilipidemic Effects of the Ethanol Extract Mixture of Ligularia fischeri and Momordica charantia in Type II Diabetes-Mimicking Mice
Table 5
Changes in relative tissue weight of the liver, pancreas, and epididymal fat in STZ/ATH and db/db/ATH mice.
Group
Relative tissue weight (Tissue weight (g) / Body weight (g))
Liver
Pancreas
Epididymal fat
ICR mice (each n=6)
Normal control
0.0343 ± 0.0035
0.0058 ± 0.0003
0.0313 ± 0.005
STZ/ATH mice (n = 6 per each group)
Vehicle
0.0758 ± 0.009
0.0069 ± 0.0009
0.0224 ± 0.003
MCE (mg/kg/day)
50
0.0627 ± 0.0026
0.0057 ± 0.0009
0.0119 ± 0.0025##
100
0.0617 ± 0.0026#
0.0067 ± 0.0003
0.0153 ± 0.0032#
200
0.0547 ± 0.0045##
0.0065 ± 0.0011
0.0145 ± 0.0019#
LFE (mg/kg/day)
50
0.0632 ± 0.0025
0.0059 ± 0.0011
0.0079 ± 0.0018##
100
0.0631 ± 0.0057#
0.0067 ± 0.0013
0.0092 ± 0.0022##
200
0.0594 ± 0.0072#
0.0062 ± 0.0018
0.0083 ± 0.0023##
MLM (mg/kg/day)
50
0.0648 ± 0.0043#
0.0065 ± 0.0009
0.0092 ± 0.0028##
100
0.0607 ± 0.0108#
0.0073 ± 0.0023
0.0129 ± 0.0024##
200
0.0594 ± 0.0052#
0.0065 ± 0.0008
0.0151 ± 0.0019#
db/db/ATH mice (n = 5 per each group)
Vehicle
0.0580 ± 0.0040
0.0060 ± 0.0007
0.0557 ± 0.0041
MLM (mg/kg/day)
50
0.0602 ± 0.0031
0.0044 ± 0.000
0.0052 ± 0.0043
100
0.0548 ± 0.0047
0.0041 ± 0.000
0.0485 ± 0.0059
200
0.0513 ± 0.003
0.0035 ± 0.000
0.0470 ± 0.005
Data are the mean ± SD (each group, n=6). p < 0.05, p < 0.01 vs. the normal control group. #p < 0.05, ##p < 0.01 vs. the STZ/ATH group. ATH, atherogenic diet D12336 (Research Diets, Inc.); MCE, ethanol extract of Momordica charantia fruit; LFE, ethanol extract of Ligularia fischeri leaves; MLM, 8:2 mixture of MCE and LFE; STZ, streptozotocin (100 mg/kg).
