Evidence-Based Complementary and Alternative Medicine / 2018 / Article / Tab 5

Research Article

Antihyperglycemic and Antilipidemic Effects of the Ethanol Extract Mixture of Ligularia fischeri and Momordica charantia in Type II Diabetes-Mimicking Mice

Table 5

Changes in relative tissue weight of the liver, pancreas, and epididymal fat in STZ/ATH and db/db/ATH mice.

Group Relative tissue weight (Tissue weight (g) / Body weight (g))
LiverPancreas Epididymal fat

ICR mice (each n=6)
Normal control0.0343 ± 0.00350.0058 ± 0.00030.0313 ± 0.005
STZ/ATH mice (n = 6 per each group)
 Vehicle0.0758 ± 0.0090.0069 ± 0.00090.0224 ± 0.003
 MCE (mg/kg/day)
  500.0627 ± 0.00260.0057 ± 0.00090.0119 ± 0.0025##
  1000.0617 ± 0.0026#0.0067 ± 0.00030.0153 ± 0.0032#
  2000.0547 ± 0.0045##0.0065 ± 0.00110.0145 ± 0.0019#
 LFE (mg/kg/day)
  500.0632 ± 0.00250.0059 ± 0.00110.0079 ± 0.0018##
  1000.0631 ± 0.0057#0.0067 ± 0.00130.0092 ± 0.0022##
  2000.0594 ± 0.0072#0.0062 ± 0.00180.0083 ± 0.0023##
 MLM (mg/kg/day)
  500.0648 ± 0.0043#0.0065 ± 0.00090.0092 ± 0.0028##
  1000.0607 ± 0.0108#0.0073 ± 0.00230.0129 ± 0.0024##
  2000.0594 ± 0.0052#0.0065 ± 0.00080.0151 ± 0.0019#
db/db/ATH mice (n = 5 per each group)
 Vehicle0.0580 ± 0.00400.0060 ± 0.00070.0557 ± 0.0041
 MLM (mg/kg/day)
  500.0602 ± 0.00310.0044 ± 0.0000.0052 ± 0.0043
  1000.0548 ± 0.00470.0041 ± 0.0000.0485 ± 0.0059
  2000.0513 ± 0.0030.0035 ± 0.0000.0470 ± 0.005

Data are the mean ± SD (each group, n=6). p < 0.05, p < 0.01 vs. the normal control group. #p < 0.05, ##p < 0.01 vs. the STZ/ATH group. ATH, atherogenic diet D12336 (Research Diets, Inc.); MCE, ethanol extract of Momordica charantia fruit; LFE, ethanol extract of Ligularia fischeri leaves; MLM, 8:2 mixture of MCE and LFE; STZ, streptozotocin (100 mg/kg).