Antihyperglycemic and Antilipidemic Effects of the Ethanol Extract Mixture of Ligularia fischeri and Momordica charantia in Type II Diabetes-Mimicking Mice
Table 6
Biochemical profiles of STZ/ATH-induced diabetic and db/db/ATH mice.
Group
Glucose (mg/dL)
Triglycerides (mg/dL)
Total cholesterol (mg/dL)
HbA1c (%)
NEFA (mEq/L)
Insulin (ng/mL)
ICR mice (each n=6)
Normal control
56.0 ± 11.7
67.0 ± 9.4
158.0 ± 6.9
4.1 ± 0.19
3.27 ± 0.643
0.26 ± 0.041
STZ/ATH mice ( n = 6 per each group)
vehicle
519.0 ± 48.
137.0 ± 22.
277.0 ± 24.
8.9 ± 0.9
6.62 ± 1.33
0.23 ± 0.054
MCE (mg/kg/day)
50
470.0 ± 34.4
132.0 ± 15.5
202.0 ± 29.1##
7.9 ± 0.52
5.63 ± 0.718
0.23 ± 0.028
100
408.0 ± 57.3##
127.0 ± 17.6
193.0 ±2 0.0##
7.6 ± 1.01
5.57 ± 0.585
0.26 ± 0.048
200
390.0 ± 90.6#
131.0 ± 17.9
184.0 ± 27.6##
7.5 ± 0.94#
4.56 ± 0.685#
0.39 ± 0.136#
LFE (mg/kg/day)
50
460.0 ± 66.9
122.0 ± 27.2
193.0 ± 25.0##
8.1 ± 0.61
5.22 ± 0.655#
0.22 ± 0.046
100
399.0 ± 63.3##
103.0 ± 14.0#
153.0 ± 12.1##
7.5 ± 0.78#
4.74 ± 0.731#
0.23 ± 0.075
200
388.0 ± 46.0##
101.0 ± 17.1#
159.0 ± 21.2##
7.3 ± 0.50#
4.02 ± 0.659##
0.25 ± 0.095
MLM (mg/kg/day)
50
451.0 ± 44.7#
132.0 ± 28.7
206.0 ± 26.6##
7.9 ± 1.05
5.23 ± 0.604#
0.21 ± 0.028
100
382.0 ± 54.9##
119.0 ± 32.2
168.0 ± 18.4##
7.0 ± 0.75##
4.82 ± 0.956#
0.22 ± 0.060
200
373.0 ± 64.2##
93.0 ± 19.7##
149.0 ± 21.5##
6.8 ± 0.68##
4.14 ± 0.514##
0.30 ± 0.067
db/db/ATH mice (n = 5 per each group)
vehicle
563.0 ± 16.0
100.0 ± 8.1
223.0 ± 25.1
-
3.37 ± 0.494
4.04 ± 0.593
MLM (mg/kg/day)
50
550.0 ± 69.5
115.0 ± 14.
226.0 ± 36.4
-
3.64 ± 0.582
3.92 ± 0.863
100
503.0 ± 54.
99.0 ± 7.7
213.0 ± 20.9
-
3.33 ± 0.447
3.28 ± 1.169
200
478.0 ± 36.
90.0 ± 7.2
212.0 ± 25.6
-
3.55 ± 0.547
3.13 ± 1.186
Data are the mean ± SEM (each group, n=6). p < 0.05, p < 0.01 vs. the normal control group. #p < 0.05, ##p < 0.01 vs. the STZ/ATH group. ATH, atherogenic diet D12336 (Research Diets, Inc.); MCE, ethanol extract of Momordica charantia fruit; LFE, ethanol extract of Ligularia fischeri; MLM, 8:2 mixture of MCE and LFE; STZ, streptozotocin (100 mg/kg).
