Antidiabetic Activities of Hydromethanolic Leaf Extract of Calpurnia aurea (Ait.) Benth. Subspecies aurea (Fabaceae) in Mice

Table 1

Hypoglycemic activity of hydromethanolic leaf extract of Calpurnia aurea in normoglycemic mice.

Group	Blood glucose level (mg/dl)
	0 hr	1 hr	2 hr	4 hr	6 hr
DW 10ml/kg	68.17 ± 7.97	70.22 ± 7.90	72.33 ± 8.09	73.5 ± 7.33	68.06 ± 7.99
CALE 100mg/kg	70.67 ± 4.36	73.78 ± 2.76	72.61 ± 3.42	66.33 ± 2.08	64.00 ± 3.88
CALE 200mg/kg	68.83 ± 4.14	73.83 ± 4.08	71.56 ± 4.59	65.56 ± 2.56	56.33 ± 4.92
CALE 400mg/kg	76.72 ± 3.21	79.11 ± 5.96	83.17 ± 3.89	67.17 ± 5.29	67.39 ± 6.61
GLC 5mg/kg	70.56 ± 5.86	54.00 ± 5.34	47.72 ± 5.03	41.89 ± 2.73	37.67 ± 2.4

Each value represents mean ± SEM; n=6 for each treatment. Compared to the negative control, compared to CALE 100mg/kg, compared to CALE 200mg/kg, compared to CALE 400mg/kg, and compared to baseline blood glucose level. p < 0.05, p < 0.01, and p < 0.001. CALE = Calpurnia aurea leaf extract, DW = distilled water, and GLC = glibenclamide.