Antidiabetic Activities of Hydromethanolic Leaf Extract of Calpurnia aurea (Ait.) Benth. Subspecies aurea (Fabaceae) in Mice
Table 4
Antihyperglycemic activity of repeated daily doses of Calpurnia aurea leaf extract in STZ-induced diabetic mice.
Group
Fasting blood glucose level (mg/dl)
Percent reduction in baseline BGL
Baseline
7th day
14th day
7th day
14th day
Diabetic control
394.11 ± 31.0
383.67 ± 45.83
387.00 ± 47.77
2.60%
1.80%
CALE 100 mg/kg
377.72 ± 43.57
251.39 ± 28.86
250.44 ± 28.84
33.45%
33.69%
CALE 200 mg/kg
314.39 ± 31.99
243.56 ± 24.58
239.94 ± 35.81
22.53%
23.68%
CALE 400 mg/kg
342.67 ± 58.07
252.72 ± 14.43
250.61 ± 14.42
26.25%
26.87%
GLC 5 mg/kg
368.50 ± 43.02
145.56 ± 26.72
136.67 ± 26.41
60.49%
62.91%
Normal control
76.83 ± 2.51
77.67 ± 2.50
78.67 ± 2.75
-1.09%
-2.40%
Each value represents mean ± SEM; n=6 for each group. Compared to the diabetic control, compared to the normal control, and compared to baseline blood glucose level. p < 0.05, p < 0.01, and p < 0.001. CALE = Calpurnia aurea leaf extract and GLC = glibenclamide.
