Modulation of Neuronal Activity on Intercalated Neurons of Amygdala Might Underlie Anxiolytic Activity of a Standardized Extract of Centella asiatica ECa233

Figure 5

Effect of ECa233 on EPSCs in ITCs recorded in every 2 min for 1 h. The maximal response was noted approximately at 15 min. Tracing showed the example of EPSCs at 0, 10, 15, 20, 30, 40, and 60 min after ECa233 1 μg/ml with bicuculline (10 μM) bath application compared with the PBS in the presence of bicuculline. The EPSCs in the presence of ECa233 1 μg/ml were normalized with respect to control condition ( = 5–10, ; pair -test).