Hepatoprotective and Anti-Inflammatory Activities of the Cnidoscolus chayamansa (Mc Vaugh) Leaf Extract in Chronic Models

Table 1

Anti-inflammatory effect of C. chayamansa extract and primary fractions F14-42 on the development of carrageenan-induced acute inflammation.

Treatment 1	Dose; (mg/kg)	T(5h)	Inhibition percentage	ED50; (mg/kg)
Carrageenan	-	0.95 ±0.03	-	-
IND	10	0.36 ±0.0	62.05%	10
CnCM	150	0.61 ±0.0	35.81%	351.53; (R^2 = 0.97)
	300	0.53 ±0.0	44.05%
	600	0.39 ±0.0	59.26%
Treatment 2
IND	10	0.28 ±0.0	63.22%	10
Primary fraction; F14-42	50	0.39 ±0.0	49.51%	50.11; (R^2 = 0.93)
	75	0.19 ±0.0	74.47%
	100	0.15 ±0.0	79.74%

Data shown as mean (±), with standard error of the mean (SEM). Treatments were i.g. administered 1 h before the Carrageenan. Statistical analysis two-way ANOVA and post hoc SNK test (p ≤0.05). Treatment 1: Carrageenan control, Indomethacin, CnCM 150 mg/kg, and CnCM 300 mg/kg. Treatment 2: Carrageenan control. Indomethacin. fraction 14-42 75 mg/kg. fractions 14-42 100 mg/kg; CnCM: extract CHCl₃:MeOH; IND: Indomethacin; n = 6.