Hepatoprotective and Anti-Inflammatory Activities of the Cnidoscolus chayamansa (Mc Vaugh) Leaf Extract in Chronic Models

Table 3

Effect of C. chayamansa extract on the biochemical parameters of Balb/C mice with hepatotoxicity induced by antiTB drugs.

Parameters	Treatments
	AntiTB	AntiTB + Silymarin	AntiTB + CnCM
		2.5 mg/kg	200 mg/kg	400 mg/kg
Creatinine; (mg/dL)	2.88±0.79	2.88±0.21	0.60±0.	0.07±0.0
Urea; (mg/dL)	51.07±5.63	68.45±5.00	50.63±8.	40.55±1.
AST; (IU/L)	198.00±17.45	256.33±25.	268.00±13.	317.00±8.6
ALT; (IU/L)	175.00±32.25	228.33±31.	393.00±76.	452.50±59.
ALP; (IU/L)	184.00±28.65	286.00±11.	252.67±38.	397.00±7.0
Cholesterol; (mmol/L)	4.30±0.25	4.50±0.24	4.23±0.30	4.10±0.05
Triacyl-glyceride; (mmol/L)	0.99±0.20	1.36±0.31	0.66±0.10	0.70±0.03
HDL; (mmol/L)	1.30±0.06	1.05±0.	0.92±0.0	0.92±0.0

Data presented as mean (±) standard error of the mean (SEM). Statistical analysis one-way ANOVA, post hoc Student-Newman-Keuls (SNK) test (p<0.05); AntiTB; AntiTB + Silymarin 2.5 mg/kg; AntiTB + CnCM 200 mg/kg; AntiTB + CnCM 400 mg/kg; AntiTB: RIF/INH/PZA mixture; AST: aspartate aminotransferase; ALT: alanine aminotransferase; ALP: alkaline phosphatase; HDL: high density lipoprotein; n=7.