Evidence-Based Complementary and Alternative Medicine

Research Article

A Network Pharmacology Approach to Uncover the Molecular Mechanisms of Herbal Formula Ban-Xia-Xie-Xin-Tang

Table 6

KEGG pathways significantly enriched with targets of BXXXT.
ClassKEGGIDDescriptionAdjusted P valueAssociated Disease
(Adjusted P value)
Aginghsa04211Longevity regulating pathway2.95×10−5DM
(5.65×10−4)
Carbohydrate metabolismhsa00500Starch and sucrose metabolism1.99×10−4DM
(5.43×10−4)
Cell growth and deathhsa04210Apoptosis9.41×10−10GC
(4.72×10−3)
Cellular communityhsa04510Focal adhesion9.11×10−4GC
(2.33×10−3)
hsa04520Adherens junction5.29×10−3GC
(4.62×10−5)
Developmenthsa04380Osteoclast differentiation1.40×10−7Colitis
(5.09×10−3)
 hsa04917Prolactin signaling pathway5.84×10−11DM;GC
(7.92×10−3;6.68×10−3)
 hsa04915Estrogen signaling pathway1.43×10−6GC
(4.72×10−3)
Endocrine systemhsa04923Regulation of lipolysis in adipocytes1.99×10−4DM
(2.90×10−6)
 hsa04920Adipocytokine signaling pathway7.58×10−4DM
(1.52×10−6)
 hsa04910Insulin signaling pathway2.55×10−3DM
(1.32×10−7)
Immune systemhsa04621NOD-like receptor signaling pathway3.31×10−10Colitis
(6.21×10−3)
hsa04620Toll-like receptor signaling pathway8.69×10−9Colitis
(2.42×10−3)
 hsa04668TNF signaling pathway3.25×10−13Colitis
(7.96×10−5)
 hsa04064NF-kappa B signaling pathway8.09×10−7Colitis
(1.95×10−3)
 hsa04370VEGF signaling pathway8.98×10−7GC
(4.72×10−3)
 hsa04068FoxO signaling pathway5.11×10−6DM
(2.00×10−5)
Signal transductionhsa04150mTOR signaling pathway4.33×10−5DM
(2.11×10−3)
 hsa04151PI3K-Akt signaling pathway5.29×10−5DM;GC
(9.05×10−3;1.22×10−4)
 hsa04012ErbB signaling pathway9.33×10−5GC
(1.19×10−3)
 hsa04014Ras signaling pathway7.58×10−4GC
(7.38×10−4)
 hsa04015Rap1 signaling pathway4.20×10−3GC
(4.62×10−5)