Hepatoprotective Activity of the Ethanolic Extract of Polygonum multiflorum Thunb. against Oxidative Stress-Induced Liver Injury

Figure 2

Effect of PME against APAP-induced mouse hepatotoxicity. Mortality (a), plasma ALT (b), and AST (c) levels were measured 6 h after the administration of water (control) or APAP. p < 0.05 compared with the control group; p < 0.05 compared with the APAP group; n = 3 in the control group; n = 10 each in the APAP and PME+APAP groups. Representative liver sections stained with hematoxylin and eosin (d) and anti-Nrf2 antibody (e) from untreated mice (left) and APAP-treated mice pretreated with either water (middle) or PME (right).

(a)

(b)

(c)

(d)

(e)