Hepatoprotective Activity of the Ethanolic Extract of Polygonum multiflorum Thunb. against Oxidative Stress-Induced Liver Injury

Figure 5

Proposed hepatoprotective mechanisms of PME. The current study demonstrated that PME can induce the nuclear translocation of the transcription factor Nrf2, induce ARE-related expression of antioxidant genes, and inhibit ROS production in hepatocyte. In addition, PME also repressed bile acid import and induced basolateral bile acid export under cholestatic liver injury. All these data supported the hepatoprotective activities of PME, including antioxidant activity and bile acid homeostasis.