Zuo Jin Wan Reverses DDP Resistance in Gastric Cancer through ROCK/PTEN/PI3K Signaling Pathway

Figure 4

PI3K contributes to ZJW-induced activation of PP1/PP2A and mitochondrial translocation of cofilin. Cells treated with ZJW (50 μg/mL) were cotreated with or without LY294002 for 24 h, and western blotting was used to detect expression levels of proteins involved in the PI3K/Akt pathway (a). Depolymerisation of F-actin and translocation of cofilin-1 from the cytoplasm to the mitochondria in SGC7901/DDP cells were detected using an immunofluorescence assay (b). Quantification of protein levels (c). P < 0.01, P < 0.001 versus control.

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