The Role of Berberine in the Prevention of HIF-1α Activation to Alleviate Adipose Tissue Fibrosis in High-Fat-Diet-Induced Obese Mice

Figure 1

Protective effects of berberine on HFD-induced obesity. Male C57BL/6 mice were fed a high-fat-diet (HFD) or normal chow diet (NC) for 16 weeks and then given BBR for 8 weeks (100mg/kg/day, BL; 200mg/kg/day, BM; and 300mg/kg/day, BH) or saline (Vehicle). Body weight (BW) was measured (n=6) (a). Fasting glucose levels quantified in overnight-fasted mice (b). Blood glucose was measured during glucose tolerance test (GTT) in overnight fasted mice (n=5) (c). Areas under the curve (AUC) were measured for GTT (d). Blood glucose was measured during insulin tolerance test (ITT) in 6-hour-fasted mice (n=5) (e). Areas under the curve (AUC) were measured for ITT (f). P < 0.05 versus NC group, P < 0.01 versus NC group; < 0.05 versus HFD group; < 0.01 versus HFD group.

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