Condition Products (classification)/formula Effective components Animals Models Daily dose Material Neurotransmitters/relative receptors Main Depression Rhodiola rosea Ethanol extract Male SD rats CMUS 1.5, 3, and 6 g/kg Hippocampus 5-HT level 5-HT↑ Depression Acanthopanax senticosus Aqueous extract Male KM mice FST 500, 1000, and 2000 mg/kg Brain 5-HT, NE, 5-HT↑ Depression Ginseng 20(S)-protopanaxadiol Male Swiss mice FST 3.75, 7.5, and 15 mg/kg Hippocampus and cortex NE and 5-HT NE↑ and Depression Licorice Liquiritin and isoliquiritin Mice FST 10, 20, and 40 mg/kg Hippocampus, hypothalamus, and cortex 5-HT and NE 5-HT↑ Depression Peony Paeoniflorin H Male SD rats CMUS 30 and 60 mg/kg Brain 5-HT/5-HIAA, NA and DA NA↑ Depression Psoralea corylifolia Psoralen Male ICR mice FST 10, 20, and 40 mg/kg Frontal cortex and hippocampus 5-HT/5-HIAA 5-HT↑ AD Eclipta alba Aqueous extracts Half male and female SD rats Aβ 25–35- infused 8 and 24 g/kg Hippocampal NE, DA, NE↑ AD Morinda officinalis Bajijiasu Male SD rats Aβ 25–35- infused 8, 24, and 48 mg/kg Brain ACh, AchE ACh↑ AD Cistanche Tubulosa (Yang-invigorating)Aqueous extracts Male SD rats Aβ 1–42-infused 100 and 200 mg/kg Cortical and hippocampal ACh, DA DA↑ PD Acanthopanax senticosus Harms Ethanol extract Male C57BL/6 mice 18–22 g, MPTP-treated 45.5 and 182 mg/kg Striatum DA, HVA DA↑ PD Panax quinqnefolism Pseudoginsenoside-F11 Male SD rats 6-OHDA-induced 3, 6, and 12 mg/kg Striatum DA DA↑ PD Astragalus Astragalus polysaccharideC. elegans strain BZ555.6-OHDA-induced 1, 2, and 4 mg/mL BZ555 nematodes DA DA↑ PD Peony Paeoniflorin Adult male C57BL/6 mice 25 g,; MPTP-treated 7.5, 15, and 30 mg/kg Striatum DA, HVA, DAT, and TH DA↑ PD Fallopia multiflora 2,3,5,4-Tetrahydroxystilbene-2-O-β -D-glucoside Male C57BL/6 mice MPTP-induced 20 and 40 mg/kg Striatum DA, DOPAC, HVA, and TH DA↑ PD Fructus Alpinia oxyphylla Ethanolic extract Zebrafish 6-OHDA-induced 6 and 12 μ g/ml Brain DA DA↑ PD Psoralea corylifolia △3,2-hydroxy bakuchiol Male SD rats MPTP-induced 5.44, 16.32, and 48.96 mg/kg Striatum DA, NE, DA↑ PD Jia-Jian-Di-Huang-Yin-Zi decoction Radix Paeonia alba, Angelica sinensis, Radix Rehmanniae, Morinda officinalis, and Cistanche Male C57BL/6 mice 25–30 g MPTP-induced 8.5, 17, and 34 g/kg Striatum DOPAC, DA, and HVA DA↑ Sleep disorders Licorice (Qi-invigorating)Ethanol extract; Male ICR mice Pentobarbital-induced sleep 50, 100, 250, and 500 mg/kg Cortex GABAA-BZD receptors GABAA-BZD↑ Sleep disorders Eleutherococcus senticosus Eleutheroside E Male ICR mice Sleep deprivation 50 mg/kg Hippocampus 5-HT and DA 5-HT↑ Sleep disorders Alpinia oxyphylla fructus Volatile oil Half male and female Wistar rats Sleep deprivation 9 and 27 g/kg Hypothalamus Glu Glu↓ Perimenopausal syndrome A derivative herbal recipe from Danggui Buxue Tang Radix Astragali,Radix Ange, Llicae sinensis, Folium Epimedii Female SD rats OVX 141, 282, and 564 mg/kg Hypothalamuses NE, DA, 5-HT, and 5-HIAA NE↓ Perimenopausal syndrome Erzhibaihe Cream Glossy Privet Fruit, Eclipta alba,Lily Female Wistar rats OVX 0.48, 0.96 and 1.92 mg/kg Hypothalamus NE, DA, and 5-HT NE↓ Perimenopausal syndrome Bushen Liaogeng Extract (BLE) RadixRehmannia, Praeparata Cistanche Cynomorium songaricum Female SD rats OVX 4.5, 9 and 18 g/kg Hypothalamus DA, NE, 5-Ht, and 5-HIAA DA↓
