Moxibustion-Simulating Bipolar Radiofrequency Suppresses Weight Gain and Induces Adipose Tissue Browning via Activation of UCP1 and FGF21 in a Mouse Model of Diet-Induced Obesity

Figure 1

Development of the M-RF Stimulator. (a) Block diagram of the M-RF Stimulator and temperature measurement system. (b) Photo for front side of the M-RF Stimulator. (c) Bipolar electrode plate (5 mm, 1.8 mm, and 3 mm for diameters of the inner circle, outer circle, and width, respectively) in the M-RF Stimulator for use in mice. (d) Temperature change (maximum temperatures of 39.9°C, 38.4°C, 37.2°C, and 37.2°C for RF-H, RF-M, RF-L, and moxibustion (Moxibustion), respectively) in Yucatan pigs. (e) Temperature change (maximum temperatures of 38.8°C, 37.9°C, and 36.7°C for moxibustion, RF-H, RF-M, and RF-L, respectively) in mice.