|
| First author, publication year | Trial location | Treatment duration, follow-up duration | Stage, severity, and duration of condition | Number of participants randomized/assessed; dropouts or withdrawals | Age (mean (SD) or range); gender (M/F) |
|
| Han; 2010 [27] | China, hospital, outpatients | 8 w, 1 m | Stage: NS | I: 50/46; 4
C: 50/47; 3 | I: 25.83 ± 5.25; 18/28
C: 24.68 ± 4.36; 14/33 |
| Severity: Pillsbury I, II |
| Duration: I: ; C: 2.15 ± 0.82 |
|
| He; 2009 [28] | China, hospital, outpatients | 3 w, NS | Stage: NS | I: 24/24; 0
C: 22/22; 0 | I: 25.2; NS
C: 23.6; NS |
| Severity: slight to severe |
| Duration: I: 20 d to 16 y; C: 1 m to 17 y |
|
| Li; 2002 [29] | NS | 6 d, 1 m | Stage: NS | I1: 200/200; 0
I2: 60/60; 0
C: 60/60; 0 | I1: 13–37; NS
I2: 14–35; NS
C: 14–33; NS |
| Severity: Samuelson 1–9 |
| Duration: I1: 14 d–15 y, I2: 7 d–13 y; C: 4 d–14 y |
|
| Liu; 2011 [30] | NS | 2 w, 6 m | Stage: NS | I: 40/40; 0
C: 40/40; 0 | I: 14–41; 6/34
C: 13–30; 7/33 |
| Severity: NS |
| Duration: I: 1 w–14 y; C: 1 w–10 y |
|
| Mo; 2005 [32] | NS | 2 w, NS | Stage: NS | I: 42/42; 0
C: 38/38; 0 | NS
NS |
| Severity: NS |
| Duration: NS |
|
| Tang; 2011 [33] | NS | 10 d, NS | Stage: NS | I: 42/42; 0
C: 42/42; 0 | NS; 11/31
NS; 7/35 |
| Severity: NS |
| Duration: 1 w–9 y |
|
| Wu; 2011 [34] | NS | 8 w, 2 m | Stage: NS | I: 40/36; 4
C: 40/35; 5 | I: 24.31 ± 4.08; 13/23
C: 23.91 ± 3.83; 13/22 |
| Severity: NS |
| Duration: I: 11.92 ± 8.93; C: 12.77 ± 9.58 |
|
| Liu; 2015 [31] | NS | 8 w, NS | Stage: NS | I: 60/50; 10
C: 58/50; 8 | I: 23.2; 27/33
C: 24; 27/31 |
| Severity: NS |
| Duration: I: 6.5 m; C: 6.1 m |
|
| Zhang; 2014 [36] | NS | 4 w, NS | Stage: NS | I: 20/19; 1
C: 20/20; 0 | I: 18–23; 2/17
C: 18–24; 5/15 |
| Severity: NS |
| Duration: I: 6 m–5 y; C: 6 m–4.5 y |
|
| You; 2014 [35] | NS | 30 d, NS | Stage: NS | I: 30/30; 0
C: 30/30; 0 | I: 25 ± 5; 17/13
C: 25 ± 5; 15/14 |
| Severity: NS |
| Duration: I: 23.36 m; C: 22.81 m |
|
| McKee; 2004 [38] | USA, outpatient clinic | 20 w, NS | Stage: NS | I1: 6/6; 2
I2: 11/11; 6
C1: 6/6; 1
C2: 6/6; 0 | I1: F 16 (2.1) M 15 (0.7); NS
I2: F 21 (3.4) M 16 (3.6); NS
C1: F 19 (4.2) M 17 (1.9); NS
C2: F 21 (1.5) M 15 (1.2); NS
|
| Severity: grade I & II mild-to-moderate nonscarring facial by dermatologist; photographs grading by Cook 1979 and lesion count |
| Duration: NS |
|
| Kim; 2012 [37] | Korea, outpatient clinic | 4 w, NS | Stage: NS | I: 11/11, 3
C: 11/11, 2 | I: M 21.5 (3.6); NS
C: M 23.3 (4.1); NS |
Severity: Korean Acne Grading System grades 2–4 (>10
papules, <20 nodules on face); |
| Duration: >3 months (chronic stage) |
|
