Investigation of Lake Hévíz Mineral Water Balneotherapy and Hévíz Mud Treatment in Murine Osteoarthritis and Rheumatoid Arthritis Models

Figure 2

Effects of balneotherapy on mechanical hyperalgesia in MIA-induced osteoarthritis (a, b, c) and CFA-induced rheumatoid arthritis (d, e, f) models. Data points represent the percentage changes of the mechanonociceptive threshold throughout the 3-week experimental periods in mice treated with Hévíz water (a, d), Hévíz mud (b, e), and combined therapy with Hévíz water and mud (c, f) (30 mins on every weekday by the end of the study), n = 6–8/arthritic groups; p < 0.05, p < 0.01, p < 0.001 versus respective controls; two-way ANOVA followed by Bonferroni’s multiple comparison test.