Table 2: Effect of enzyme-treated RJ treatment on menopausal symptoms.

Treatment groupChange compared to baseline
Week 4Week 8Week 12Week 16 (post intervention)

Hot flashesPlacebo0.2080.0260.3630.372
RJ
SweatingPlacebo0.2720.1490.4150.533
RJ
InsomniaPlacebo0.7880.5290.9610.694
RJ
Light sleepPlacebo0.5680.7520.6760.954
RJ
IrritabilityPlacebo0.0800.2070.2520.420
RJ
AnxietyPlacebo0.0670.0630.0460.229
RJ
Anxious triflesPlacebo0.3430.1360.2130.645
RJ
Depressive moodPlacebo0.0810.1250.0750.185
RJ
FatiguePlacebo0.5760.5020.2840.475
RJ
Eye strainPlacebo0.6970.6550.8850.778
RJ
ForgetfulnessPlacebo0.4350.1560.3730.750
RJ
DizzinessPlacebo0.1690.0910.3330.884
RJ
PalpitationPlacebo0.9780.2290.1520.587
RJ
Chest tightnessPlacebo0.5220.3120.2570.056
RJ
HeadachePlacebo0.4990.8190.6020.673
RJ
Neck stiffnessPlacebo0.7080.2310.8050.971
RJ
Backache and low back painPlacebo0.1560.4400.0400.535
RJ
Joint painPlacebo0.7190.7530.6530.723
RJ
Cold hands and feetPlacebo0.2290.2550.2470.697
RJ
Numbness in the legs or armsPlacebo0.7990.9370.2090.574
RJ
Sensitive to soundsPlacebo0.6040.2190.0980.518
RJ

Menopausal symptoms scores were assessed monthly with menopausal symptoms questionnaire of Japanese women (Visual Analog Scale); RJ, enzyme-treated Royal Jelly. All values are mean ± SD.