Flavonoid Extract from Propolis Inhibits Cardiac Fibrosis Triggered by Myocardial Infarction through Upregulation of SIRT1

Figure 6

FP suppressed the migration and proliferation of CFs induced by Ang II. (a) Representative images showing that FP inhibited Ang II-stimulated CF migration. (b) Representative images showing that SIRT1-siRNA counteracted the effect of FP on CF migration. (c) Quantitative analysis of (a). (d) Quantitative analysis of (b). (e) FP inhibited Ang II-stimulated CF proliferation. (f) SIRT1-siRNA counteracted the effect of FP on CF proliferation. Data are expressed as the mean ± SEM; = 6 per group; P < 0.05 versus the control or Ang II+NC+FP group; ^#P < 0.05 versus the Ang II or Ang II+SIRT1-siRNA group.

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