Flavonoid Extract from Propolis Inhibits Cardiac Fibrosis Triggered by Myocardial Infarction through Upregulation of SIRT1

Figure 9

FP decreased ROS and MDA content in myocardial tissue of MI rats and ROS content in Ang II-induced CFs. (a) FP decreased MDA content in myocardial tissue of MI rats.(b) FP decreased ROS content in myocardial tissue of MI rats. (c) FP decreased ROS content in CFs induced by Ang II. (d) SIRT1-siRNA counteracted the effect of FP on ROS content in CFs induced by Ang II. Data are expressed as the mean ± SEM; = 6 per group. P < 0.05 versus the sham, control, or Ang II+NC+FP group; ^#P < 0.05 versus the MI, Ang II, or Ang II+SIRT1-siRNA group.

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