Simultaneous Quantification of Gallic Acid, Bergenin, Epicatechin, Epicatechin Gallate, Isoquercitrin, and Quercetin-3-Rhamnoside in Rat Plasma by LC-MS/MS Method and Its Application to Pharmacokinetics after Oral Administration of Ardisia japonica Extract

Table 3

Intraday, interday accuracy, and precision of 6 compounds ().

Compounds	Concentration (ng/mL)	Intraday		Interday
		Accuracy (%)	RSD (%)	Accuracy (%)	RSD (%)
Gallic acid	2	99.4	6.59	96.0	9.67
	6	93.8	9.14	101	9.12
	20	85.5	4.33	86.1	7.57
	200	104	3.87	108	7.31
Bergeninum	2	106	9.08	103	16.2
	6	100	10.7	99	10.4
	20	114	6.40	108	11.4
	200	109	13.4	111	13.2
L-Epicatechin	4	92.8	5.07	96.5	12.2
	12	97.3	8.15	88.9	12.9
	40	94.9	9.63	96.3	12.8
	400	90.0	15.7	94.8	9.62
(−)-Epicatechin gallate	2	93.4	16.0	108	9.97
	6	93.9	7.11	94.6	15.8
	20	86.6	12.2	90.0	14.3
	200	103	10.7	98.9	13.8
Isoquercitrin	1	110	9.45	104	12.4
	3	90.3	7.54	92.4	13.4
	10	101	11.8	101	8.50
	100	109	4.59	102	8.10
Quercetin-3-rhamnoside	0.4	89.1	14.9	91.4	15.6
	1.2	85.6	4.42	87.9	11.8
	4	95.7	14.7	90.1	12.5
	40	99.9	5.01	95.0	8.05