Scolopendra subspinipes mutilans Extract Suppresses Inflammatory and Neuropathic Pain In Vitro and In Vivo

Figure 5

Effects of SSM treatment on sciatic functional index (SFI) and paw withdrawal latency (PWL) following sciatic nerve crush injury. (a) Walking track footprints in SNCI rats. (b) Plot showing the time-dependent changes in SFI value in each group. (○) Sham operation group, (●) SNCI-induced group, (□) SNCI-induced and 0.1 g/kg SSM-treated group, (▲) SNCI-induced and 1 g/kg SSM-treated group, and (◇) SNCI-induced and 10 g/kg SSM-treated group. (c) The PWL in the plantar test in each group. (A) Sham operation group, (B) SNCI-induced group, (C) SNCI-induced and 0.1 g/kg SSM-treated group, (D) SNCI-induced and 1 g/kg SSM-treated group, and (E) SNCI-induced and 10 g/kg SSM-treated group. The results are presented as the means ± standard errors of the mean (SEMs).  < 0.05 compared to the sham operation group.  < 0.05 compared to the SNCI-induced group.

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