Research Article

Exploring the Pharmacological Mechanism of Danzhi Xiaoyao Powder on ER-Positive Breast Cancer by a Network Pharmacology Approach

Table 3

Cluster of known target-breast cancer PPI network.

ClusterScoreNodesEdgesGenes

144.125491059MAPK8, MMP1, STAT1, HMOX1, F2, AR, PPARG, ICAM1, NOS3, KDR, SRC, MTOR, STAT5B, MAPK14, FOXO3, IGF1, STAT3, CCND1, MAPK1, PGR, EGFR, VEGFA, BCL2L1, CDKN1A, MMP2, IL6, TP53, RAF1, HIF1A, ERBB2, MYC, JUN, IL8, BIRC5, TGFB1, IL2, SERPINE1, CTNNB1, PTEN, FOS, PPARA, JAK2, RELA, ERBB3, ESR1, HSP90AA1, AKT1, BCL2, TNF
2101045CXCL11, ADRA2A, CHRM2, CXCL2, ADRA2C, OPRM1, CHRM4, ADRA2B, CXCL10, PTGER3
382284ERBB4, CAT, VCAM1, CDK1, BAX, IL1B, CCL2, Quercetin, IL4, SIRT1, RUNX2, GSK3B, HSPB1, INSR, CDK2, PIK3CA, PTGS2, IGFBP3, IL10, CCNB1, RB1, CDK4
43.92139CASP3, HSPA5, WT1, RUNX1, CHEK2, CAV1, AHR, FOSL1, ESR2, MMP3, NCOA3, SLC2A4, PIK3CG, EIF4E, IRF1, MYB, NFKBIA, IKBKB, CHEK1, GJA1, CASP8
53.8821833Hederagenin, CALM3, GABRA2, GABRA5, GABRA6, stigmasterol, GABRA3, ADH1B, 1-methoxyphaseollidin, licoricone, CYP1A2, GABRA1, isorhamnetin, KCNH2, GSTM2, XDH, 18103-41-8, KCNMA1
63.4291524RXRA, CHRM3, ADRA1A, CYP3A4, NR1I2, ADRA1B, ADRA1D, GSTM1, F10, glabridin, PLAT, HTR2A, CYP2E1, CALM1, CALM2
73.33345CYP1A1, NFE2L2, kaempferol, GSTP1
831521ABCG2, NOS2, MAPK10, HSF1, PLK1, CHUK, TOP2A, CCNA2, NCOR2, IFNG, GATA3, IL1A, HDAC4, TOP1, EZH2
9333PLAU, E2F1, E2F2
10333PPP3CA, PIM1, ACACA
11333SLC6A2, ferulic acid, MAOB